THE CALCIUM SIGNALING SYSTEM: AIMING FOR A COMPREHENSIVE EXPLANATION OF AGING AND THE DEMENTIA-ALZHEIMER’S SYNDROME
Ara S. Khachaturian, Zaven S. Khachaturian
The overarching aim of this perspective paper is to reformulate the calcium hypothesis from the standpoint of systems theory to address the complexity of the calcium signaling system to maintain homeostasis of cytosol calcium ion concentration essential for the optimal functioning of a neuron. The intent is to recast the earlier attempt of the calcium hypothesis to formulate a unifying theory linking brain aging and the dementia-Alzheimer syndrome in terms of a systems failure model1. This re-definition of the problem of the linkages between aging and dementia will encourage the development of novel in silico models and applications of machine learning algorithms and other quantum computing modeling approaches to tackle the complexity of neuronal calcium regulation and, eventually, describe systems failures in brain aging-dementia continuum.
Ara S. Khachaturian ; Zaven S. Khachaturian ; (2023): The Calcium Signaling System: Aiming for a Comprehensive Explanation of Aging and the Dementia-Alzheimer’s Syndrome. Vitality, Medicine & Engineering. http://dx.doi.org/10.14283/VME.2023.2