01/2023 journal articles
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EDITORIAL: VISION FOR VITALITY, MEDICINE & ENGINEERING
Ara S. Khachaturian
VM&E 2023;6:1-3
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CITATION:
Ara S. Khachaturian (2023): Editorial: Vision for Vitality, Medicine & Engineering. Vitality, Medicine & Engineering. http://dx.doi.org/10.14283/VME.2023.1
THE CALCIUM SIGNALING SYSTEM: AIMING FOR A COMPREHENSIVE EXPLANATION OF AGING AND THE DEMENTIA-ALZHEIMER’S SYNDROME
Ara S. Khachaturian, Zaven S. Khachaturian
VM&E 2023;6:4-16
Show summaryHide summaryThe overarching aim of this perspective paper is to reformulate the calcium hypothesis from the standpoint of systems theory to address the complexity of the calcium signaling system to maintain homeostasis of cytosol calcium ion concentration essential for the optimal functioning of a neuron. The intent is to recast the earlier attempt of the calcium hypothesis to formulate a unifying theory linking brain aging and the dementia-Alzheimer syndrome in terms of a systems failure model1. This re-definition of the problem of the linkages between aging and dementia will encourage the development of novel in silico models and applications of machine learning algorithms and other quantum computing modeling approaches to tackle the complexity of neuronal calcium regulation and, eventually, describe systems failures in brain aging-dementia continuum.
CITATION:
Ara S. Khachaturian ; Zaven S. Khachaturian ; (2023): The Calcium Signaling System: Aiming for a Comprehensive Explanation of Aging and the Dementia-Alzheimer’s Syndrome. Vitality, Medicine & Engineering. http://dx.doi.org/10.14283/VME.2023.2
THE ROLE OF VASCULAR-METABOLIC FACTORS ON COGNITIVE IMPAIRMENT WORKSHOP REPORT BY THE CAMPAIGN TO PREVENT ALZHEIMER’S DISEASE AND THE BRAIN WATCH COALITION
Ara S. Khachaturian, Zaven S. Khachaturian
VM&E 2023;6:17-22
Show summaryHide summaryThe grand challenge for healthcare systems worldwide is the escalating costs of prolonged care for older people with various chronic disabling disorders. Among these protracted brain incapacitating conditions, progressive deterioration of cognitive functions, different types of dementia, and Alzheimer’s syndrome profoundly impact quality of life, economic and psycho-social, and burdens of family caregivers. This report provides an overview of the deliberations at a think-tank workshop organized by PAD2020 before the AAIC 2022 in July 2022. The participants of this forum included leading experts representing government, academia, industry, and the philanthropic sector. The overarching aim for convening this workgroup (WG) was to seek suggestions for a potential global action plan, a comprehensive public health initiative, aiming for a significant reduction in the incidence of cognitive impairment or dementia-Alzheimer syndrome. The future aim of this undertaking (specifically, the pending task of this WG) is to develop a roadmap for a coordinated large-scale effort to demonstrate the putative efficacy of reducing risks for cognitive impairment/dementia-Alzheimer syndrome via existing interventions for modifiable risks of vascular-metabolic disorders. The primary rationale for such global action plans is that a practical, broad-scale approach to this growing public health crisis problem will substantially reduce the demand and cost for prolonged personalized care of people with dementia. The proposed initiative will require a greater focus on research and investments in therapeutic strategies to delay the onset of cognitive impairment and reduce dementia-related morbidity. Such an approach would emphasize addressing modifiable risks for dementia with affordable, accessible interventions that target modifiable risks for vascular and metabolic disorders likely to result in the most tremendous success.
CITATION:
Ara S. khachaturian ; Zaven S. khachaturian ; ; (2023): The Role of Vascular-Metabolic Factors on Cognitive Impairment Workshop Report by the Campaign to Prevent Alzheimer’s Disease and the Brain Watch Coalition. Vitality, Medicine & Engineering. http://dx.doi.org/10.14283/VME.2023.3